Listen to our experts explain who would need this panel and how to interpret this report.
For our Foundation/Methylation/Wellness Nutrigenomic Panel, 21 genes have been chosen by our experts to be analyzed for SNPs (single nucleotide polymorphisms). The report algorithms and customized software will take the patient's genetic results and create nutritional and lifestyle recommendations along with recommended lab work and health precautions based upon SNP results and their clinical expertise. The built-in proprietary software takes out the guess work and allows the provider to recommend the proper nutrition and health advisements safely by your DNA results.
This panel will provide insight into the following:
and B12 Metabolism (including MTHFR, FOLR, MTRR...)
Who needs this gene panel?
ØEveryone Seeking Better Health and Nutritional Guidance
ØAnyone with Dopamine Deficiency Symptoms
ØAnyone with Serotonin Deficiency Symptoms
Why should we care about Methylation?
ØMethylation involves the addition of a “methyl” chemical
group to a substrate
ØUsed in over
250 biochemical processes in the body
utilized in major functions of:
ØCell turnover and repair
ØEnergy (mitochondrial) function
From Dr. Stewart: The term methylation describes a biochemical process that is utilized in the body for transport of nutrients, energy production and in gene modulation. In patients with decreased methylation activity (i.e. methylation deficiency), there are significant shortcomings in the ability to execute a variety of important chemical functions in the body. These shortcomings can leave the body unprotected from the everyday assault of environmental and infectious agents, sluggish in neurotransmitter production and slow to recover from inflammatory damage.
This shortfall can result in a wide range of medical conditions including neurological issues, such as seizures, migraines, dizziness, depression, anxiety, OCD, ADD/ADHD, developmental delay, autism, dementias and memory issues, chronic persistent infections, auto-immune disease, neural tube defects, infertility and pregnancy complications. Appropriate supplementation with the proper methylated vitamins and nutrients will bypass the genetic and acquired deficits and restore appropriate function of the pathway resulting in improvement in these complicated syndromes.
The proper functioning of the methylation cycle is essential for CRITICAL reactions in the body.
If you are a registered GX Sciences account holder CLICK HERE to view an example report.
Methylation (MTHFR) Testing & Folate Deficiency
The methylation cycle is the ideal pathway to focus on for nutrigenomic analysis because the proper function of this pathway is essential for over 250 processes in the body.
What is MTHFR? What is Methylfolate?
Methylenetetrahydrofolate reductase, or MTHFR, is a key regulatory enzyme in the metabolism of folate. It also refers to a specific gene that plays a major role in the body's methylation process. Both the enzyme and the gene have the same name, MTHFR. The gene's role is very complex, and recent discoveries have been focused around the MTHFR gene polymorphisms (or variants). These polymorphisms are often referred to as 'mutations' or 'defects' because of the problems they cause in the body.
Most often when you hear someone talk about MTHFR, they are actually referring to one of the two common MTHFR gene mutations that causes this MTHFR enzyme to become imperfect and therefore much less effective.
Simply stated, MTHFR most often refers to a genetic mutation that inhibits the body's ability to methylate or convert folic acid from the food we eat into Methylfolate.
Methylfolate is most often referred to as the 'active' or usable form of folate that our cells require. Because the body's cells cannot actually use folic acid, it must first go through a metabolic pathway or 4-step conversion process to become Methylfolate before the cells can use it . It is this metabolic pathway that the MTHFR gene defect inhibits and cause methylation deficiencies and/or neuro-immune syndromes.
The learnings about this gene defect have come out and taught us that there are as many as 50+ variants of the MTHFR gene. However, only two are considered 'common' defects that today’s MTHFR Blood Test checks for and are the: 677 and 1298 (discovered in 1995 and 2001).
MTHFR Gene Variations
Everyone receives one copy of the MTHFR gene from each parent. This means a person could have any one of the following combinations as well as the issues that go with it:
Normal / C677T - More susceptible to neuro-immune syndromes, environmental damage, depression, central nervous system issues, etc. (referred to as Heterozygous)
Normal / A1298C - More susceptible to neuro-immune syndromes, environmental damage, depression, central nervous system issues, etc. (referred to as Heterozygous)
A1298C / A1298C - Denoted as 1298CC - Much worse for the above problems (referred to as Homozygous)
C677T / C677T - Denoted as 677TT - Similar to 1298CC plus heart disease, blood clots, and more (referred to as Homozygous)
C677T / A1298C - Susceptible to all of the above and worse for strokes, heart disease, blood clots, etc. (referred to as Compound Heterozygous)
Methylation, Folic Acid, and Folate Deficiency
Methylation issues like being unable to fully convert folic acid to the active, usable form of folate (methylfolate) can lead to a folate deficiency. Methylation issues can be behind why folate deficiency occurs, such as when there is an inadequate amount of folate, an increased need in the body for folate, or when the body loses folate faster than usual. No matter the case, folic acid, folate, or methylfolate issues can leave patients with feelings of fatigue, irritability, sleep issues, anxiety, brain fog, and aches and pains. These side effects can be greater for some, leading to a diagnosis of fibromyalgia, an autoimmune disease, or anemia. Symptoms can be worsened by excessive alcohol consumption, kidney problems, and certain medications.
Genetic Testing for Methylation & Folate Deficiency
Methylfolate (5MTHF) contributes to the creation of neurotransmitters and immune cells, processing of hormones, production of energy, and detoxing chemicals and toxins. Since the methylation cycle interacts with over 200 processes in the body, it’s important in find out where your methylation issues lie to understand the root of the problem. That way, you can determine the best course of action to better health rather than trying to solve a slew of side effects. Genetic testing for methylation can help doctors and their patients better understand where in the methylation cycle an issue may be occurring because of genetic variants.
If folate deficiency is determined as the cause, or aggravating factor, of your methylation issues, a folate-rich diet may be enough to get you back on course. Vegetables like romaine lettuce, spinach, cauliflower, broccoli, beets, and lentils are great sources of natural folate. Additionally, be aware not to overcook your food, which can destroy the vitamins and nutrients, diminishing the nutritional value.
For women trying to get pregnant and those struggling with more complex or severe issues in the methylation cycle, an orally supplement of active folate like Methyl Folate Plus may be needed.
Now Available! Dr. Stewart's 5 segment workshop series "Methylation, Mutations & Beyond the MTHFR".
View Now For Details:
Statement from Dr. Stewart: Many abnormalities (high folic acid in blood serum, low or high homocysteine, MTHFR mutation / heterozygous or homozygous) can point to a methylation deficiency. I find that many of my patients will respond better if you ease into the methylation protocol. Suggested use is begin with the Methylation Complete Sublingual OR Neuro-Immune Stabilizer Cream for about 2 weeks by itself and then add the Methyl Folate Plus if you feel it is necessary or with a homozygous result or heterozygous compound polymorphism result.