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Communication in the nervous system is accomplished by specialized chemicals called Neurotransmitters. These chemicals are typically specialized amino acids that are sent as a signal from a neuron to another cell. The ability of nervous system to function normally can be affected by genetic variants that can alter the ability of neurons to produce a specific neurotransmitter, the ability to breakdown a neurotransmitter or the ability to reuptake the neurotransmitter.

The GX Sciences Neurotransmitter Panel consists of 10 gene variants (SNPs) that have been chosen by our medical experts which play a significant role in the:

o Production of the Dopamine and Serotonin

o Balance of Glutamate to GABA

o Breakdown of the Dopamine, Norepinephrine and Epinephrine

o Efficiency of reuptake of Serotonin

o Sensitivity of Serotonin Receptor

Utilizing our proprietary SNP Genius software, the Neurotransmitter Panel will take an individual patient’s DNA genetic findings and interpret them through the GX Sciences Precision Supplementation algorithm to determine the exact therapeutic need of the patient.

Who needs this panel?

Ø Anxiety

Ø Depression

Ø Mood Fluctuations

Ø Focus Issues

Ø Memory Disorders

Ø Poor response to anxiety / depression medications

Ø Sleep Initiation Disorders

Ø Sleep Architecture Disorders

All About Neurotransmitters

Have you ever found yourself getting into a mood at the beginning of the day and not being able to shake it? Or do you find yourself going through life and emotionally gliding through whatever comes your way? No matter which you consider yourself, there is a connection between mood and genetics. For example, those with the COMT single-nucleotide polymorphism, or SNP, experience a difficult time calming down or regulating excitatory neurotransmitters. But what are neurotransmitters (NTs) and their relationship to SNPs?

Brain Chemistry of Neurotransmitters

Billions of neurons exist in the brain. These cells share information with other nerve cells through electrical impulses, allowing for thought and communication throughout the body. Neurotransmitters inform many necessary processes like getting your stomach to digest, your heart to beat, or your lungs to breathe. While all neurotransmitters transmit information, they do not all do so in the same manner or with the same intention.

Genes Associated With Depression

Depression is not genetically inherited, but the potential for depression in each person is epigenetically modified by environment, stress, genetic makeup and nutritional health. In the nutrigenomic world, the depression risk factors are associated with two genes that are associated with a higher risk of developing depression. These genes do not guarantee any person will get depression. The specific genes are the MAO and COMT. Both of these genes affect the speed at which neurotransmitters are broken down and cleared from the post synaptic receptor. In both MAO A and B homozygous and COMT homozygous, the mono-amines are cleared from the receptor site in a sluggish manner. This makes the post synaptic neuron less adaptable to changes in neurotransmitter status and leads to a higher likelihood of depression and/or anxiety in that patient. By assisting these mutations with methyl donors (ie taurine, methionine, choline, inositol), the practitioner can speed the clearance of the neurotransmitters and lessen the likelihood of developing depression.*

How Neurotransmitter Genetic Testing Can Help

The issues that accompany an imbalance of inhibitory and excitatory neurotransmitters can be exacerbated by specific genetic SNPs in neurotransmitter markers like COMT, MAO-A, MAO-B, GAB 12. Drugs (recreational and/or prescription), neurotoxins, stress, alcohol, poor diet, and caffeine can also fuel symptoms by encouraging these SNPs to further express themselves.

GX Sciences’ neurotransmitter genetic testing shares what SNPs you have within the neurotransmitter markers. This information allows GX Sciences to recommend nutritionally support specific to those genetic shortcomings. Ultimately, neurotransmitter genetic testing lets doctors and their patients understand their underlying issues with neurotransmitter function and implement personalized solutions.

Listen to Dr. Stewart explain the gut / brain connection and how they influence each other's function.

Serotonin & Dopamine - Technically the Only Two Things You Enjoy

There are “inhibitory” neurotransmitters and “excitatory” neurotransmitters. Inhibitory neurotransmitters work to counterbalance excitatory neurotransmitters and are considered the “feel-good” neurotransmitters. GABA, serotonin, and dopamine are among a few. They allow the brain to calm and feel balanced. Excitatory neurotransmitters are responsible for motivation, focus, anxiety, stress, and more. Norepinephrine and epinephrine (noradrenaline and adrenaline) are classified as excitatory, stimulating the brain.

Imbalance of Inhibitory & Excitatory Neurotransmitters

It’s not uncommon for the body to run out of inhibitory neurotransmitters when one has overactive excitatory neurotransmitters. When inhibitory and excitatory neurotransmitters are not working together and are imbalanced, moods like anger, agitation, anxiety, depression can occur. Change in weight, sleep issues, and poor concentration can also be a byproduct. An estimated 86% of Americans have an imbalance between inhibitory and excitatory neurotransmitters.